PharmPK Discussion - PK model for maternal-placental-fetal transfer

• On 23 Jan 2007 at 20:41:29, "Yan Xu (WFD)" (yan.xu1.at.bms.com) sent the message
  

  
  All,
  
  Does anyone know the appropriate PK model for maternal-placental-
  fetal transfer? I have a cpd that have transplacental transfer from
  mother to fetus. In addition, metabolites of the cpd were detected in
  the fetal circulation, indicating metabolism in the placental and/or
  the fetal compartment. Any comments are welcomed.
  
  Thanks,
  Yan
  
  

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• On 24 Jan 2007 at 00:57:46, jbyczkowski.at.netscape.net sent the message
  

  
  You may find a good example of PBPK model for transplacental
  transfer, which I expanded for lactational transfer, in the following
  publications and the references therein:
  
  Clewell HJ, Gearhart JM, Gentry PR, Covington TR, VanLandingham CB,
  Crump KS, Shipp AM.  Evaluation of the uncertainty in an oral
  reference dose
  for methylmercury due to interindividual variability in
  pharmacokinetics. Risk
  Analysis 1999; 19 : 547-558.
  
  Byczkowski, J.Z., and Lipscomb, J.C.: Physiologically Based
  Pharmacokinetic Modeling of the
  Lactational Transfer of Methylmercury. Risk Anal. 21: 869-882, 2001.
  
  Hope it will help you.
  Best wishes.
  
  Janusz Z. Byczkowski, Ph.D.,D.Sc.,D.A.B.T.
  Consultant
  212 N. Central Ave.
  Fairborn, OH 45324-5006
  voice (937)878-5531
  e-mail januszb.-a-.AOL.com
  homepage: http://members.aol.com/JanuszB/index.html
  JZB Consulting web site: http://members.aol.com/JanuszB/consult.htm
  
  

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• On 24 Jan 2007 at 09:45:51, "Peter Moate" (moate.-a-.vet.upenn.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  To Yan,
      You might find the following reference pertinent to your question.
  Regards,
      Peter Moate
  
  Faichney, G. J., A. A. Fawcett, and R. C. Boston. 2004. Water exchange
  between the pregnant ewe, the foetus and its amniotic and allantoic
  fluids.
  Journal of Comparative Physiology B, Biochemical, Systemic, &
  Environmental
  Physiology. 174(6):503-510.
  
  

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