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Hi, can any one provide literature reference for absolute plasma flow
rates (not as a percentage or fraction of cardiac output) in rats for
the following
Portal vein
Kidney
Brain
Liver
Thanks.
Neil
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Neil,
here are blood flows:
Portal vein 9.8 mL/min
Kidney 9.2 ml/min
Brain 1.3 mL/min
Liver 13.8 mL/min
Hematocrit 46%
See Davies and Morris. Pharmaceutical Research 10(7) 1093-1095.
1993... or alternately get a hold of a Documenta Giegy for all other
species as well. You will not get plasma flows but can approximate
from the blood and viscosity calculations as to what the flow will
model to be.
good luck,
sanjeev
Sanjeev Thohan, PhD
Director, DMPK
Exelixis, Inc
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