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I am planning to investigate Fe absorption from an oral anti-anemic
iron preparation using a labeled 59Fe (beta emittor) . Our current
limit of quantification with liquid scintillation counting (LSC) is
between 0.1 to 1 Becquerel/mL blood or serum. Do you have any
information on how the sensitivity can be improved, and whether
accelerator mass spectrometry is a useful tool for such isotope and
could offer advantage over LSC.
I am also looking for some information about the allowed radiation
dose for human use from such Fe preparation.
Highly appreciated your input.
Dr Youssef Hijazi
Drug Metabolism and Pharmacokinetics
Novartis Pharma A.G.
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