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The following message was posted to: PharmPK
Hi All,
Could anybody explain me the differences between intraperitoneal and
subcutaneous routes of administration as far as therapeutic efficacy
of a drug is concerned.
I found a subcutaneous route significantly more effective than that of
intraperitoneal injection (at the same dose and same formulation) for
a drug which doesnt undergo metabolism and fully excreted intact by
kideny. The drug is highly water soluble.
Answer to this question with appropriate reference if any is
appreciated.
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The following message was posted to: PharmPK
What kind of effect are you measuring? SUBQ injection may have
prolonged presence at the site of injection and therfore levels in
the plasma may last longer although plasma concentrations may not be
as high as that of IP injection. If the effect you are measuring
depends more on maintaining concentrations above a certain level,
SUBQ may have better efficacy.
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The following message was posted to: PharmPK
Dear Adane ,
> "What kind of effect are you measuring?"
I am measuring antiosteoporosis effect (BMD and related bone formation
parameters) of a bisphosphonate
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A possible explanation could be chemical interaction- for example
with divalent cations- of bisphosphonates when comparing one route
with another, which is a very common finding in this particular type
of drugs (and diminishes its systemic bioavailability). The
comparison of the amount of bisphosphonate excreted in urine is the
only way to ensure similar level of systemic exposition in this case.
In my opinion, for bisphosphonates, intraperitoneal route should not
be used (this route will never be used in humans) (the subcutaneous
route is not common, either)
Kind regards
Nelida Mondelo
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