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Hi all -
When Kp parameters for PBPK are determined through steady state
achieved by infusion, are they expected to be the same when one
reaches steady state by subchronic po dosing?
In other words, if a compound has a given distribution kinetics upon
po dosing (such as delayed brain exposure compared with plasma
pharmacokinetics) and the ratio brain/plasma changes over time, will
that not still be the case for each new dose even at steady state?
On the other hand, for the case of IP infusion, would that ratio at
steady state not be constant over time?
Thanks in advance for your responses.
Dario
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The following message was posted to: PharmPK
You can use the saphenous and/or submandibular veins.
Hello Dario,
As I understand, it will depend upon the relative magnitude of
absorption rate constant ka / infusion rate, distribution clearance
CLD and Kp of tissue and elimination clearance.
Following reference discusses this
Pitfalls in Pharmacokinetic Multicompartment Analysis. Liang et al.,
Journal of Pharmacokinetic and Pharmacodynamics, Vol:26, No-2, 1998
Varun Goel
Graduate Student, Pharmacometrics
Experimental and Clinical Pharmacology
University of Minnesota,
Minneapolis, MN-55414
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