PharmPK Discussion - Testing of insulin on animals

• On 8 Aug 2007 at 10:47:43, Nilanjana Das (dasnilanjana.-a-.yahoo.com) sent the message
  

  
  Hello,
           I have come across papers where insulin formulations have
  been tested on non-diabetic animal models to maintain basal level of
  insulin. I am confused as to why these formulations were tested on
  non-diabetic animals and not on diabetic animals. I would be
  immensely grateful if someone kindly clarifies my doubt.
  Thanks.
  Nilanjana
  
  

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• On 9 Aug 2007 at 07:37:09, amrutesh puranik (amruteshs.aaa.hotmail.com) sent the message
  

  
  hi nilanjana
  mostly oral insulin formulation will be tested on normal animals to
  see the hypoglycemic effect.
  if you still have doubts please fwd me the article for better
  understanding.
  regards
  
  

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• On 11 Aug 2007 at 10:50:07, Nilanjana Das (dasnilanjana.aaa.yahoo.com) sent the message
  

  
  Hello,
           I am working with insulin and having problems regarding in-
  vivo studies. I have come across papers where insulin formulations
  have been tested on non-diabetic animal models to maintain basal
  level of insulin. I am confused as to why these formulations were
  tested on non-diabetic animals and not on diabetic animals. I would
  be immensely grateful if someone kindly clarifies my doubt.
  Thanks.
  Nilanjana Das
  
  

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• On 15 Aug 2007 at 00:11:40, "jiang zhigang" (jiangzhigangcn.aaa.hotmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  Hi,Nilanjana Das ,
  I think the most probable reason is non-diabetic animal model was
  simple ,and easy to determine the dose-response relationship, just
  like the dose of most medicine printed in textbook came from health
  animal. Second, there are too many interference factors and
  uncertainties came with the building of diabetic animals.
  
  

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