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All,
As I indicated previously, I believe rate of absorption plots are
superior to cumulative amount absorbed plots in characterizing
absorption pattens. I cited the reference when I discussed this
previously, but did not have a reprint. Someone from Boomer was kind
enough to provide me a copy, and those of you who want it can simply
send me an email to this Boomer address with the phase "absorption
reprint request" in the title. I am NOT enclosing it herein so as to
not get involved in copyright issues. The paper is:
Boxenbaum, H. Pharmacokinetic determinants in the design and
evaluation of sustainedrelease dosage forms. Pharmaceutical Res. 1:
8288 (1984).
I must point out that a few of my colleagues were critical of my
assertion about rate of absorption plots, including no one less than
John Wagner.
A great Excel (formerly in Lotus) program ("Absplots") written by Bob
Shumaker and Gary A Thompson is available gratis that allows easy
calculation of cumulative absorption amounts (fractions) and rate of
absorption for drugs that exhibit mon, bi, or tri-exponential decay.
It is only available from Bob Shumaker at: [see below - db]
The reference for this program is: Shumaker, R.C., H. Boxenbaum &
G.A. Thompson. ABSPLOTS: A Lotus 123 spreadsheet for calculating drug
absorption rates. Pharmaceutical Res. 5:247248 (1988).
Best wishes to all, Harold Boxenbaum
--
Harold
Bob Shumaker is at Eisai Pharmaceuticals based at NJ. His email id is Robert_Shumaker.-at-.eisai.com
Manish
Watson Pharmaceuticals, Inc
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