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Someone may inform me the CV (coefficient variabilidade
intraindividual) in the diclofenaco sodico capsules?
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Dear Jose:
A very good question, and a very general one. How do we find
out the standard deviation or CV% of the meds we give to people? It is
an important source of uncertainty in therapy, and in the routine
practice of therapeutic drug monitoring and dosage individualization
for patients. It does not seem to be readily available. In the PDR -
for example, I could not find it for Lanoxin. It is as significant a
source of uncertainty, for example, as the error of the assay used to
measure the concentrations of the drug, and, I would guess, of
similar, but totally neglected, magnitude. In our MM-USCPACK clinical
software, one can enter the SD of the drug dose as a polynomial, and
so can specify the known error of the drug dosage in the routine care
of the patient. It leads to a still deeper understanding of what is
going on with the patient. It is a quantity which should (and easily
can) be known for each drug. It should be made easily available in the
PDR, especially for drugs which have potential toxicity, and which
need precise dosage.
Very best regards,
Roger Jelliffe
Roger W. Jelliffe, M.D. Professor of Medicine,
Division of Geriatric Medicine,
Laboratory of Applied Pharmacokinetics,
USC Keck School of Medicine
2250 Alcazar St, Los Angeles CA 90033, USA
email= jelliffe.at.usc.edu
Our web site= http://www.lapk.org
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The following message was posted to: PharmPK
It has been awhile but Clarke's Isolation and Identification of Drugs
had
Monographs which included for some materials, assay and PK data
including
error terms. I have not seen the newer Clarkes Analysis of Drugs and
Poisons but it may contain some of that information as well.
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The following message was posted to: PharmPK
For what its worth we have just completed a small study looking at
diclofenac in plasma as well as other fluids. We found that in 17
patients,
the mean concentration was 24.1 ng/mL with a standard deviation of
28.4ng/mL, which means a cv of well over 100%. Subjects were taking
100mg
slow release at night and samples were taken after 7 days treatment
about 12
hours later. Subjects, male and female were quite a heterogenous
group, but
were compliant as far as we could tell.
Hope that gives some idea.
Graham Mould, PhD
Consultant Pharmacist
Email: gmould.aaa.gcpl.co.uk
Surrey Technology Centre
Surrey Research Park, Occam Road
Guildford, Surrey GU2 7YG
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