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The following message was posted to: PharmPK
Saluggia (I), 03/31/2008
Dear collegues,
has anyone information about the excretion pathway of
Indium? It is a radionuclide labelled to antibodies for diagnostic
studies and I am interested in knowing if one can find it, when it is
not linked to the antibody, in urine or faecal samples.
Thank you very much.
Sandro Ridone
Sandro Ridone, PharmD, MSc
ENEA-Italian National Agency for New Technologies, Energy and the
Environment
Research Centre of Saluggia
Department of Biotechnologies, Agro-Industry and Health Protection
Radiation Protection Institute
strada per Crescentino, 41
13040 Saluggia (VC)
ITALY
e-mail: sandro.ridone.at.saluggia.enea.it
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The following message was posted to: PharmPK
Dear Sandro,
A Google search will give you all the information you will need.
You also may want to look at:
Harwood SJ, Webster W, et al. Comparison of Human Biodistribution and
Differences Between 131Iodine and 111Indium Labeled B72.3 Monoclonal
Antibody. Cancer Research (Suppl.), 1990; 50: 932s-936s.
Webster WB, Harwood SJ, Carroll RG, Morrissey MA. Pharmacokinetics of
111In-Labeled B72.3 Monoclonal Antibody in Colorectal Cancer
Patients. The Journal of Nuclear Medicine 1992; 33: 498-504.
Webster WB, Harwood SJ, Carroll RG, Morrissey MA. A reply to: Mean
Time Parameters Reveal Differences in the Pharmacokinetics of
Indium-111 and Iodine-131-labeled B72.3 Monoclonal Antibody. The
Journal of Nuclear Medicine 1992; 33: 2248-2249.
Webster WB, Laven DL. Pharmacokinetics and Biologic Distribution
Studies of Indium-111-Labeled Monoclonal Antibodies. New Perspectives
in Cancer Diagnosis and Management 1993; 1: 12-19.
Cordially,
Will
William Webster, PharmD, FCCP, BCPS
9525 Blind Pass Rd
Courageous 1001
St Pete Beach, FL 33706
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