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Hi.
Does anyone have a good reference to the plasma concentration of
morphine necessary to give analgesia in humans (or some other mammals)?
Thank you!
Janicke
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Janicke,
It varies over orders of magnitude just in humans due to tolerance,
let alone
other species.
Dale
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Morphine analgesia is not related to plasma concentration and is
complicated by the delay in transfer across the blood-brain barrier.
I am
not aware that anybody has yet adequately modeled this relationship
because
of species differences in transporters involved in the process of
morphine
entering the brain. You would need concurrent CSF samples and that
poses
ethical issues. The issue of M-6-G generation in the brain would also
have
to be incorporated into this relationship.
Dr. Daniel S. Sitar
Professor and Head, Dept. of Pharmacology and Therapeutics
Professor, Dept of Internal Medicine (Clinical Pharmacology)
Web Address: www.umanitoba.ca/medicine/pharmacology
Email: sitar.aaa.cc.umanitoba.ca
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Daniel:
The methods of choice for determining transport of drugs into the
brain are through the use of noninvasive imaging methods, both PET and
MR spectroscopy. There has been very significant work on the transport
of opioids into the brain. A recent review is by Lever: "PET and SPECT
imaging of the opioid system: receptors, radioligands and avenues for
drug discovery and development", published in Current Pharmaceutical
Design. 13(1):33-49, 2007 discusses recent results in such studies.
Daniel Sitar wrote:
PharmPK - Discussions about Pharmacokinetics
Pharmacodynamics and related topics
--
Professor Walter Wolf, Ph.D. Distinguished Professor of Pharmaceutical
Sciences
Director, Pharmacokinetic Imaging Program
Department of Pharmaceutical Sciences, School of Pharmacy
Chair, Biomedical Imaging Science Initiative
University of Southern California 1985 Zonal Ave., Los Angeles, CA
90089-9121
E-Mail: wwolfw.-at-.usc.edu
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