PharmPK Discussion - NAT2 Specific substrate with available metabolite

• On 11 Jan 2008 at 11:28:15, "Fabrice Guillet" (fabrice.guillet.-at-.xenoblis.com) sent the message
  

  
  Hi all,
  We would like to assess N-acetyl-transferase NAT2 activity and we are
  looking for a specific substrate.
  
  1_Sulfamethazine could be a good one. But we can't found a supplier
  for its acetylated metabolite.
  
  2_Caffeine could be a good one too, and I find that its NAT2
  metabolite is AFMU (5-acetylamino-6-formylamino-3-methyluracile).
  
  For this product, we can't found a supplier too.
  I don't understand because it seems to be a common test to determine
  the rate of acetylation.
  
  Is there someone here, who knows a supplier, who is a supplier, or who
  knows other specific substrates of NAT2 (with available metabolite)?
  
  All Your suggestions are highly appreciable.
  Thanks and Regards.
  Fabrice Guillet
  XENOBLIS
  France
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)