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Dear All,
Can anybody help me to get the information about Pharmacokinetic
Parameters for the drug PROPOFOL
Regards
Sujatha
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This might help
PHARMACOKINETICS OF PROPOFOL (DIPRIVAN) IN ELDERLY PATIENTS - all 3
versions "
T KIRKPATRICK, ID COCKSHOTT, EJ DOUGLAS, WS NIMMO - British Journal of
Anaesthesia, 1988 - British Jrnl Anaesthesia
Page 1. Br. J. Anaesth. (1988), 60, 146-150 PHARMACOKINETICS OF
PROPOFOL (DIPRIVAN)
IN ELDERLY PATIENTS T. KIRKPATRICK, ID COCKSHOTT, EJ DOUGLAS AND WS
NIMMO ...
Cited by 155 - Related Articles - Web Search - SFX.-a-.Rhodes
[CITATION] Pharmacokinetics of Propofol (Diprivan) in elderly patients
CJD Kirkpatrick , EJ Douglas, WS Nirnmo - Br. J. Anaenth, 1988
Cited by 1 - Related Articles - Web Search
Key authors: T KIRKPATRICK - E Douglas - I COCKSHOTT - W NIMMO
s.o.o
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The following message was posted to: PharmPK
sujatha wrote:
> Dear All,
>
> Can anybody help me to get the information about Pharmacokinetic
> Parameters for the drug PROPOFOL
Dear Sujatha,
Here are some good papers with conventional 3 compartment models for
propfol:
Barr J, Egan TD, Sandoval NF, Zomorodi K, Cohane C, Gambus PL, et al.
Propofol dosing regimens for ICU sedation based upon an integrated
pharmacokinetic-pharmacodynamic model. Anesthesiology. 2001
Aug;95(2):324-33.
Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, et
al. The influence of method of administration and covariates on the
pharmacokinetics of propofol in adult volunteers. Anesthesiology.
1998;88:1170-82.
Schuttler J, Ihmsen H. Population pharmacokinetics of propofol: a
multicenter study. Anesthesiology. 2000;93:1557-60.
If you are interested in how a physiologically based model can be used
with a drug like propofol (high clearance, rapidly acting) have look at
my paper on the topic:
Upton RN, Ludbrook G. A physiologically based, recirculatory model of
the kinetics and dynamics of propofol in man. Anesthesiology. 2005
Aug;103(2):344-52.
Regards, Richard
--
Dr Richard Upton
Principal Medical Scientist/Senior Lecturer
Discipline of Anesthesia and Intensive Care
Royal Adelaide Hospital/University of Adelaide
North Tce, SA 5000, Australia
richard.upton.at.adelaide.edu.au
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