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The following message was posted to: PharmPK
Hello,
could you please explain about "mathematical approaches in
pharmacokinetic-pharmacodynamic modeling for tolerance induced by
opioids".
Thanks
krishna akkisetti,
M.S. pharmacology and toxicalogy,
NIPER,
INDIA.
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The following message was posted to: PharmPK
Krishna,
You could try reading this general review of PKPD models for tolerance.
Gardmark M, Brynne L, Hammarlund-Udenaes M, Karlsson MO.
Interchangeability and predictive performance of empirical tolerance
models. Clin Pharmacokinet. 1999 Feb;36(2):145-67.
Nick
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
Zealand
n.holford.-a-.auckland.ac.nz
www.health.auckland.ac.nz/pharmacology/staff/nholford
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The following message was posted to: PharmPK
Hi Krishna,
Take a look at this paper:
Sharma A, Ebling WF, Jusko WJ: Precursor-dependent indirect
pharmacodynamic response model for tolerance and rebound phenomena. J
Pharm Sci. 1998 Dec;87(12):1577-84.
Toufigh
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