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The following message was posted to: PharmPK
Dear all,
Could anyone please explain to me the focus and types of ADME assays
conducted in the different stages of drug discovery and development? A
good reference will also be very helpful. Thank you very much.
Regards,
Ling
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The following message was posted to: PharmPK
Ling, a great reference for this is Walter Korfmacher's book:
http://www.amazon.com/Using-Mass-Spectrometry-Metabolism-Studies/dp/0849319633/ref=sr_1_1?ie=UTF8&s=books&qid=1250539023&sr=8-1
He has a new edition coming out in November, but this covers a lot of
ground.
Mickey O'Brien, MS
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Dear Ling
Hope this reference may help you.
Current Topics in Medicinal Chemistry 2001, 1, 353-366
Regards
Khalid
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The following message was posted to: PharmPK
Thank you for the reference, Mickey. It is a very good reference book.
I am wondering if there is another reference that addresses more on
the differences in ADMEt assay design and how it contributes to
decision-making at different stages of drug discovery-development.
One example: simple CYP450 inhibition screening is usually performed
in discovery stage while quantitative information (Ki, IC 50) is
acquired in development stage. What is the consideration underlying
these ADMEt assay design?
Thanks a lot.
Ling
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