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Does anyone have any information on which animal species would be most predictive of rectal absorption from a suppository?
Thanks - dave
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Vaginal and Rectal Administration
Carol S. Auletta
Pharmaco LSR, Inc., East Millstone, New Jersey, U.S.A.
Vaginal and rectal routes of administration of test substances are not
often used in animal testing procedures. However, these routes are
almost obligatory when therapeutic agents intended for vaginal or
rectal use in humans have to be evaluated for safety in animals.
Applicable study designs and experiences with these routes are
described in this report.
Key Words: Vaginal administration * Rectal administration * Mucous
membrane toxicity
International Journal of Toxicology, Vol. 13, No. 1, 48-63 (1994)
DOI: 10.3109/10915819409140655
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