Back to the Top
Dear friends,
Can any one help me in classifying new chemical entities based on the
caco2 permeability.
(based on the apparent permeability)
Best regards
Subramanian
Back to the Top
Hi Subramanian,
The permeability classification based on the Papp isLow permeable less
than 2 X 10 6 cm/secModerate permeable 2-20 X 10 6 cm/secHigh
permeable more than 20 X 10 6 cm/sec
Regards
--Naveed Shaik Abdul
Back to the Top
The following message was posted to: PharmPK
Dear Navid,
Is there any reference for this classification? I mean BCS using caco-2
permeabilility.
[There is:
http://www.fda.gov/AboutFDA/CentersOffices/CDER/ucm128219.htm
-db]
Back to the Top
Hi Subramanian,
I missed the negative sign in my earlier post
--Naveed Shaik Abdul
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Caco2 permeability" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)