PharmPK Discussion - Classification for protein binding results

• On 5 Mar 2009 at 09:25:31, "Luo, Rosa.at.Neurocrine.com" (rluo.at.neurocrine.com) sent the message
  

  
  Hello,
  
  Is there any FDA guidance, literature review or "rule of thumb" on how
  to "classify" protein binding results?
  
  i.e. What is considered highly protein bound, 90%, 95% or 98%?  What
  is considered moderate protein bound?  Etc.
  
  Thanks!
  
  Best,
  
  Rosa
  
  

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• On 6 Mar 2009 at 11:43:32, Marjorie Cotler (msgcot.at.optonline.net) sent the message
  

  
  The following message was posted to: PharmPK
  
  What we used across sites when I worked was > 95% Highly bound,
  70-95% Moderately bound, and < than 70 Low binding. Stanley Cotler
  
  

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• On 6 Mar 2009 at 11:43:32, Marjorie Cotler (msgcot.-at-.optonline.net) sent the message
  

  
  The following message was posted to: PharmPK
  
  What we used across sites when I worked was > 95% Highly bound,
  70-95% Moderately bound, and < than 70 Low binding. Stanley Cotler
  
  

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• On 6 Mar 2009 at 14:58:37, "Luo, Rosa.-at-.Neurocrine.com" (rluo.-at-.neurocrine.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hello,
  
  Thank you!
  
  This is what we have been going by.  However, I'm wondering how this
  system is established, if there is any literature reference for it.
  
  Best,
  Rosa
  
  

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• On 8 Mar 2009 at 14:50:19, stanleycotl.aaa.aol.com sent the message
  

  
  Rosa,
  This "classification" came about in part of a literature search and
  general agreement of the people involved in determining protein
  binding of NCE to provide a common standard among the sites of the
  company I worked for.  I will look in my files to see if there an
  actual paper that can be used as a reference.  I tried your e-mail
  address but it failed..
                                                         Stanley Cotler
  
  [Email is getting even more interesting. One PharmPK member was
  concerned about their messages not getting through. It seems that
  their ISP was blocking their outbound email because of the footer on
  PharmPK messages that was included as part of the response. (I wonder
  how many others have been affected by this filtering.) It appears that
  the 'pharmacy' part of the URL caused the block. You may notice I've
  now removed that link. It seems that pharmacy is a bad word on the
  internet :-( - db]
  
  

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