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Dear All,
We are thinking of using clozapine (with its metabolite clozapine N
oxide) as a probe drug for CYP1A2 in trying to evaluate the effect of
an herbaldrug/supplement on the activity of CYP1A2. We are aware that
caffeine and the relevant metabolites would be more acceptable but due
to inaccessibility to the important metabolites, we are looking at the
possibilty of using clozapine and the relevant metabolite which are
more accessible
I will appreciate your comments
Titilayo Fakeye
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