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Dear all,
I am doing a project on population pharmacokinetics of
rifampin and its metabolite desacetyl rifampin.For this we are in need
of pure sample of desacetyl rifampin. Could anyone of you, please
advice from where to obtain pure sample of desacetyl rifampin and a
method for estimating the same. My hearty thanks in advance for your
earnest replies.
rinu mary xavier
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hello,
you can get des acetyl rifampicin from sandoz and method to estimate
both rifampicin and desacetyl rifampicin by lc-ms/ms is mobile phase
acn; 2mM ammonium acetate buffer 80:20 ratio, flow rate 0.5ml/min,
column any c18 or you can also go for a monolithic column. Extaction
can be done by taking 100 microliltre sample and extacting with 2ml of
acn.
regards,
gagandeep singh
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