PharmPK Discussion - Drug excretion

• On 7 Nov 2009 at 14:49:38, rahul vats (rahulvats1983.-at-.gmail.com) sent the message
  

  
  Dear all,
  
  In oral excretion study i wanted to know whether unabsorbed drug,
  which one can recover from feces should be considered as a excretory
  amount.
  
  i am little bit confused with contribution of biliary excretion and
  unabsorbed drug while collecting feces and its data interpretation.
  
  Regards,
  Rahul Vats
  
  

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• On 9 Nov 2009 at 09:07:45, JigneshKotecha.-a-.torrentpharma.com sent the message
  

  
  Dear Rahul,
  
  Amount recovered from feces is considered as excretory amount to know
  the major route of excretion. To rule out involvement of biliary
  excretion, one need to perform experiment by IV route. Appearance in
  fecal matter suggests biliary excretion involvement in overall
  excretion by fecal route.
  
  regards,
  
  Jignesh
  
  

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