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Dear All,
Did you come across compounds completely bound to plasma proteins and
microsomes (i.e fu = 0), and if so how would you calculate the
clearance for those compounds using binding terms?
Regards,
Raghav.
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Raghav: This might provide some insight-
How to Calculate Clearance of Highly Protein-Bound Drugs during
Continuous Venovenous Hemofiltration Demonstrated with Flucloxacillin
Brigitte Meyera, Salwa Ahmed el Gendyd, Georg Delle Karthc, Gottfried
J. Lockerb, Gottfried Heinzc, Walter Jaegerd, Florian Thalhammera
aDepartment of Internal Medicine I, Division of Infectious Diseases,
bDepartment of Internal Medicine I, Intensive Care Unit,
cDepartment of Internal Medicine II, Division of Cardiology, and
dInstitute of Pharmaceutical Chemistry, University of Vienna, Vienna,
Austria
Address of Corresponding Author
Kidney & Blood Pressure Research 2003;26:135-140 (DOI:
10.1159/000070997)
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