Back to the Top
Hi,
I need to know the hepatic clearance or hepatic extraction ratio of
various drugs (e.g. cyclosporin, nifedipine, aniline, omeprazole,
etc...). May I know which reliable resource has a comprehensive
listing of the average values?
Also, what range of ER or CL(H) is usually considered as high
clearance or low clearance? I need classify the drugs as high
clearance or low clearance drugs.
Thanks!
Back to the Top
Hi :
The hepatic clearance values are based on liver blood flow (Q). <30%
of liver blood flow is considered low clearance, while >70% is
considered high clearance.
Parnali Chatterjee
E-mail: Parnalic.aaa.hotmail.com
parnali_chatterjee.-at-.yahoo.com
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "High or low hepatic clearance drugs" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)