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Hello-
I'm a newbie to this field and am trying to find a suitable method to
determine tissue:plasma partition coefficients in rat for a very
hydrophilic and rapidly cleared compound (log Kow= -2.43). Literature
searches seem geared almost exclusively towards methods for lipophilic
volatile compounds only (Kaneko, Jepson, Gargas, etc) and I know
nothing of algorithms. Could anyone please send a protocol for
measuring this? I'm looking at brain, placenta and whole body (fetal
tissues mainly).
Thanks!
J Maucher
biologist
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