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Has anyone any experience with using midazolam or triazolam as an in
vivo probe of BOTH CYP3A4 and (O+N)-glucuronidation? I was going to
use lorazepam and nifedipine for this purpose, but a single drug would
by nice. I am more interested in the midazolam, since I need to
administer the drug IV, and the triazolam would require more
formulation work.
Many thanks in advance.
Paul
--
Paul R. Hutson, Pharm.D.
Associate Professor
UW School of Pharmacy
777 Highland Avenue
Madison WI 53705-2222
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Hi Paul
You may find the following paper useful:
In vitro and in vivo glucuronidation of midazolam in humans
http://www.ncbi.nlm.nih.gov/pubmed/19371318
Masoud
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Paul:
Joe Bertino has used midazolam as a CYP2A4 probe and has many citations
of it's utility. However, I have not seen any reports with
glucuronidation processes. I would contact him for more information.
Thanks
Chris
Chris Destache, Pharm. D.
Professor of Pharmacy Practice, Internal Medicine, Medical Microbiology
and Immunology
Creighton University School of Pharmacy & Health Professions
Hixson-Lied Bldg. Rm 114
2500 California Plaza
Omaha, NE 68178
Email Destache.aaa.creighton.edu
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The following message was posted to: PharmPK
Dear Masoud:
Thanks for this reference. It comes close to what I need, but in
using rabbits I was hoping for a method that just uses plasma. I
think I'll give it a try (IV midaz, with blood samples for (1OH and 1-
OH glucuronide) and report back.
Paul
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