PharmPK Discussion - Model for Cumulative Excretion in Bile

• On 17 Jun 2009 at 15:40:20, (Richard.Knapp.at.sanofi-aventis.com) sent the message
  

  
  I am collecting bile samples over four to six intervals for up to 8 hr
  after an intravenous administration of a compound. The amount of dosed
  compound is measured in each sample and the sample volume is used to
  calculate the total amount of the compound. I can plot the data as the
  fraction of the administered dose (percent) relative to the mid-point
  of the collection interval. These data are well fitted by a simple
  hyperbolic function in WinNonlin and this gives me an asymptote
  ("Emax") value that I would like to interpret as the maximum amount of
  compound that can be excreted. This would be most helpful for
  situations where it is obvious that the curve is still rising at 8 hr.
  
  My question to the group is, does anyone have a literature reference
  for this approach? I have found a few articles that appeared to use
  this approach but without any reference. Worse still, I would like to
  apply this approach to cumulative urine data plotted in the same way.
  
  Thanks -
  
  Richard Knapp
  
  

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• On 18 Jun 2009 at 00:42:09, Dimiter Terziivanov (terziiv.at.yahoo.com) sent the message
  

  
  Dear Richard,
  
  The following paper could answer some of your questions: Terziivanov,
  D.et al. Pharmacokinetics and quantitative characterization of
  Cefotiamexcretion ways after i.v. administartion in patinets after
  cholecystectomy. Eur J ClinPharmacol., 1986, 30, 439-444.
  
  Kind regards,
  Dimiter
  --
  Dimiter Terziivanov, MD,PhD,DSc,
  Professor and Head, Clinic of Clinical Pharmacology and
  Pharmacokinetics,
  Univ Hosp "St. Ivan Rilski", 15 Acad. Ivan Geshov st, 1431 Sofia,
  Bulgaria
  
  

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