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Dear all,
What is the current opinion on monitoring para-O-sulphate
rosiglitazone, in addition to rosiglitazone and N-demethyl
rosiglitazone, in a human drug interaction study with a CYP2C8/2C9
inhibitor when rosiglitazone is used as probe substrate of CYP2C8?
If para-O-sulphate rosiglitazone is recommended, does anybody have
knowledge or literature references that address the bioanalytical
method for para-O-sulphate rosiglitazone in plasma?
Kind regards,
Ping
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Ping,
The following reference may be helpfulBr J Clin Pharmacol. 2005 Jan;
59(1):70-9. The effect of trimethoprim on CYP2C8 mediated
rosiglitazone metabolism in human liver microsomes and healthy subjects.
Ganesh Mugundu
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