PharmPK Discussion - Pharmacokinetics of nanoparticulate vaccine systems

• On 12 Jan 2009 at 23:43:50, "vamsi krishna" (vamsikrishna.karuturi.at.gmail.com) sent the message
  

  
  Hi,
  
  How do we evaluate Pharmacokinetics and biodistribution of
  nanoparticulate based vaccines. PLGA microencapsulated antigen is
  evaluated as a good vaccine, it has good efficiency of producing
  antibodies. I am a new graduate student, I have checked online if
  anyone has done Pharmacokinetic study for the nanoparticulate based
  vaccines. I would be happy if some one outlines the necessary studies
  to be carried out and parameters to be evaluated. Please make some
  suggestions even if you some one doesn't know what to do exactly.
  
  Hope to hear some good news soon.
  
  Sincerely,
  Vamsi Krishna Karuturi,
  Graduate Research Assistant,
  Department of Pharmaceutical Sciences,
  University of Nebraska Medical Center,
  Omaha, Nebraska 68105.
  
  

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• On 14 Jan 2009 at 07:19:59, "Ed O'Connor" (efoconnor.at.cox.net) sent the message
  

  
  The following message was posted to: PharmPK
  
  Vamsi:  I would think as a model you could use some of the approaches
  done
  with liposomal carriers.
  
  Edward F. O'Connor, PhD
  78 Marbern Drive
  Suffield, CT 06078
  
  efoconnor.at.cox.net
  
  

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• On 14 Jan 2009 at 21:51:46, sihorkarv.at.drreddys.com sent the message
  

  
  Dear Vamsi,
  
  The disposition kinetics of the carrier may influence the
  pharmacokinetics
  and distribution of any active (drug/vaccine) as compared to when they
  are
  given in the naive form (no carrier). The reason for using delivery
  systems
  (carriers like nanoparticle, liposomes etc) is to make use of the
  disposition kinetics of the carrier itself due to either their
  long-circulatory nature or else their preferential endolysosomal uptake.
  Depending upon the purpose of and selection of carrier (liposome,
  nanoparticle etc), the pharmacokinetic profile of the active accrodingly
  may vary and can be tailored to the needs to some extent.
  
  For a detailed information on the plan of PK and disposition kinetics of
  vaccines/genetic vaccines, books and literature references by Kreuter,
  Gregoriadis, Paphadjopoulus, Torchilin and other experts can be
  referred.
  
  Hope this will help.
  
  

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