PharmPK Discussion - PK of clopidogrel

• On 15 Dec 2009 at 17:23:17, Huilin Huang (hnghuilin.aaa.gmail.com) sent the message
  

  
  Hi,
  we're doing a study to correlate the influence of pharmacogenetics on  the response to clopidogrel. as part of this study, we will not only  measure platelet reactivity of subjects(PD), but also measure serum lvls  of clopidogrel-trough(PK). Can you advise on what reagents will be  needed, what the procedure should be like for the PK bit. e.g. does the  patient need to fast, skip his dose of clopidogrel?
   read in several articles that the active metabolite of clopidogrel is  not stable and requires derivatisation with  2-bromo-3'-methoxyacetophenone so as to be stable. but not sure if there  are other alternative reagents. or how much reagent should be used etc.  i hope you can enlighten me.
   Thanks very much for your help!!!=)
   Regards,
  Huilin
  
  

  Back to the Top

• On 16 Dec 2009 at 21:40:31, Dominique Paccaly (paccaly.-at-.gmail.com) sent the message
  

  
  May be the rationale for pharmacokinetic (in this case very inaccurate)  is not the principal criteria when you have access directly to the end  response (good accuracy).  And the rationale of the study is  pharmacogenetics.
  Dominique Paccaly, Pharm D.
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)