PharmPK Discussion - Tablet in tablet formulation

• On 5 Oct 2009 at 13:47:32, punit parejiya (punit_pharma.-a-.yahoo.co.in) sent the message
  

  
  Dear Pharmacokinetists,
  i am research scholar, pursuing Ph.D. on Controlled release.
  i am formulating Tablet with in tablet to accomodate loading dose and
  maintanance dose in coat and core respectively.i want to know how much
  dose should i kept in outer coat layer to provide a loading dose for
  once a daily Tab in Tab formulation. is there any specification that
  within 1 hr or 2hrs some fixed % of drug should release for once daily
  formulation.
  Sincerely yours,
  
  Punit Parejiya
  (punit_pharma.aaa.yahoo.co.in)
  
  

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• On 6 Oct 2009 at 06:44:59, "Zafar Iqbal , Prof Dept of Pharmacy UOP Iqbal" (zafar_iqbal.-at-.upesh.edu.pk) sent the message
  

  
  Dear Punit,
  Generally about 30-35% of the dose is required as loading dose and
  then rest of the drug will be kept as loading dose.
  
  Dr Zafar
  
  

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• On 7 Oct 2009 at 19:30:52, Milind Padki (mmpadki.-a-.gmail.com) sent the message
  

  
  Hi Punit,
  I am not sure that the concept of a loading dose (to quickly take you
  into the therapeutic window) is relevant anymore. Consistent blood
  levels within the window happen only at steady state - 5 days of
  dosing or so. So long as you approximately match input to output, the
  levels will be maintained.
  In first 2 hours 10-30% drug seems to be released for many 24-hour
  commercial SR products. This is probably because they cannot control
  the initial "burst" based on current matrix technologies, rather than
  from any ideas of a "loading dose".
  To get a uniform API content in the coating will not be easy: The RSD
  needs to be below 6%, and pan coating is not geared for that: typical
  variations in film coats (film deposited on each tablet) are 25%.
  Hope this helps.
  Milind
  
  

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