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Does anyone have any experience in conducting Bronchial Alveolar Lavage studies in healthy human volunteers for a drug candidate targeted to the lungs? Any pointers in CROs/clinical sites will be appreciated.
Thanks
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The following message was posted to: PharmPK
We published on this technique some time ago. You might find the
reported details helpful in the design of your own study. The literature
citation is:
O'Neill SJ, Sitar DS, Klass DJ, Taraska VA, Kepron W, Mitenko PA (1986) The
pulmonary disposition of theophylline and its influence on human alveolar
macrophage bactericidal function. Amer Rev Respir Dis 134, 1225-1228.
Dr. Daniel S. Sitar
Editor in Chief, Journal of Clinical Pharmacology
Professor Emeritus
Dept of Internal Medicine (Clinical Pharmacology)
Dept of Pharmacology and Therapeutics
Back to the Top
The following message was posted to: PharmPK
We published on this technique some time ago. You might find the
reported details helpful in the design of your own study. The literature
citation is:
O'Neill SJ, Sitar DS, Klass DJ, Taraska VA, Kepron W, Mitenko PA (1986) The
pulmonary disposition of theophylline and its influence on human alveolar
macrophage bactericidal function. Amer Rev Respir Dis 134, 1225-1228.
Dr. Daniel S. Sitar
Editor in Chief, Journal of Clinical Pharmacology
Professor Emeritus
Dept of Internal Medicine (Clinical Pharmacology)
Dept of Pharmacology and Therapeutics
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