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Dear all,
Can any body tell me how to calculate Microsomal clearance of compound using metabolite formation Vs time data?
Some paper i gone through for calculation of clearance but either they are using %remaining Vs time or Vmax/Km data.
Eagerly waiting for your reply
regards,
Rahul Vats
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Dear Rahul,
You need to be carefull about using metabolite formation in order to determined a coupond clearance. In fact, you may have several metabolites beeing formed from the original parent. Why don't you use the AUC of the parent concentration to calculate the CL?
Paulo Paixao
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