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Dear Group,
I am rather new to this program and modeling in general. I am trying to simulate a study in TS using a 1 compartment model.
I have fit my individual data in winnonlin and calculated the individual values for the parameters: ka, V, ke.
At this point I am not up for tackling NONMEM and just want to simulate a study using those values.
In my computation box, I have Vc mean, Vc eta, and Vc expression - Vcmean *exp(Vceta) And the same for the other parameters.
What I am confused about is how to enter the values in the block for Vcmean and Vceta.
I am assuming that my data is lognormal for Vc. So first, should I log transform data first then enter the mean in the box and list the type as lognormal. Or do I enter the mean as a raw value then list type as lognormal? Or are neither of these correct? Likewise I have a similar question for how to handle the standard deviation box? Note, I want to avoid having negative values. Also, I put the variable at study level.
Next question is for the eta box. I put this at subject parameter for level. Again do I transform the data or use untransformed data to enter mean and sd for eta. Again I am confused about this one, but I am assuming eta has a mean of zero with a sd. However, if you enter lognormal distribution you get an error because zero is not allowed?
Again I realize there are many complexties etc. but at this stage I am only trying to do a basic simulation to generate some simulated data similar to actual data. My goal is to get something working before doing something more advanced.
Thanks in advance,
Mario
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You might also get some answers on the Clinical Trial Simulator Tool at
the Pharsight extranet and forums
http://www.pharsight.com/extranet
I'm pretty sure you can register for free and post your question, and
other users of the software, and Pharsight people who developed and
support the software might be able to answer. (See a post on the Bebac
forum for more info
http://forum.bebac.at/forum_entry.php?id=4931
Regards,
Paul.
--
Paul Hurley
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