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Found this old archived topic. Can you elaberate more for the relation of enterohepatic circulation and effective half life ?
http://www.boomer.org/pkin/PK08/PK2008132.html
Lisa
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The following message was posted to: PharmPK
Hi Lisa,
The "effective half-life" is estimated from the observed extent of
accumulation in plasma (and known dosing interval) after repeated dosing as
described by Boxenbaum et al. The "effective half-life" is simply that
half-life consistent with the observed accumulation. Therefore, for a drug
undergoing EHC, the extent of accumulation in plasma after different dosing
regimens may be predicted from the effective half-life.
However, there has been a lot of discussion around assessment of
accumulation on PharmPK and the use of "effective half-life" has been
criticised. The relationship between drug accumulation and dosing interval
is comprehensively reviewed in [Sahin and Benet, Pharm Res 25:2869 (2008)].
Regards,
Charlie
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