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Hello,
I would like to initiate a discussion about reporting pharmacokinetic parameters for metabolites using non-compartmental analysis. Typically for a metabolite, full AUC, partial AUC or metabolite to parent ratio is reported; however, some papers report metabolite half-life or MRT.
The question is, to define a metabolite kinetics, which parameters "should" or "should not be" reported.
Any suggestions are greatly appreciated.
Fatemeh Akhlaghi
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