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Dear All,
We are dosed one CNS compound by three different routes per-oral, intraduodenal and intraperitoneally with same dose i.e. at 10 mg/kg, by using the same vehicle in different groups of rats .Interestingly per-oral treated animal concentrations was found very low but intraduodenal and intraperitoneal concentrations was found 10 fold higher than P.O treated animals. The compound was stable in both acidic and alkaline pH. The molecule was metabolically stable in hepatocytes and intestinal isolated CYP enzymes. I interested to know from experts what could be the possible reason for higher concentration in intraduodenal and intraperitoneal treated groups.
Regards,
CH.Satyanarayana
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Dear Satyanarayana
Can you provide some information on the vehicle? This may be relevant. Regards David
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Dear David,
We are used 1 % Tween-80 soution as a vehicle in all routes.
best regards,
Satyanarayana.CH
DMPK
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The following message was posted to: PharmPK
Binding to bile products?
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