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Dear colleges,
I have a question about the simulation of PK-PD model in Winnolin.
The Fig1 is the PD model, and the Fig2&3 is the PK-PD model of the iv. bolus. (Please see the figure in attachment)
In the Fig1, C: drug concentration in blood; E: effect of drug. In the Fig3: Ce: is the drug concentration in effect compartment.
After experiment we have the E (effect), t (time) and C (drug concentration in blood).
If we used the C-t curve, we can get the PK parameters, such as k.
If we used the E-C curve and equation of Fig1, we can get the parameters, such as Emax, EC50, S.
However, we do not have the Ce, how could we can simulate the PD parameters such as the Ke0 and k1e by using the equation of Fig3?
Thanks,
Guo
[Figures at http://www.pharmpk.com/images/pk28Jan11.png
- db]
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The following message was posted to: PharmPK
Dear Guo,
Attachments are not allowed with this service. If you are using the WNL library model to fit the link model, then the Ce values are displayed on the far right hand side of the summary table output. If you need further support, please email the attachments to support.-at-.parsight.com.
Dan
--
Daniel Weiner, PhD
SrVP & GM Pharsight and Tripos - CertaraT Companies
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