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The following message was posted to: PharmPK
Hello,
I need your help in understanding the procedure of analysing (NCA
Analysis) IV Bolus,Oral and Infusion data contained in a single input
within a single run
for ex
Sub ID Time Concentration Route Dose
1 0.083 1496.520 IV bolus 1mg/kg
1 0.25 564.950 IV bolus 1mg/kg
1 0.5 234.970 IV bolus 1mg/kg
1 1 129.700 IV bolus 1mg/kg
1 2 18.180 IV bolus 1mg/kg
1 4 2.700 IV bolus 1mg/kg
1 8 0.290 IV bolus 1mg/kg
1 12 0.170 IV bolus 1mg/kg
1 24 0.150 IV bolus 1mg/kg
1 0 0 Oral 20mg/kg
1 0.25 8.30 Oral 20mg/kg
1 0.5 81.4 Oral 20mg/kg
1 1 505 Oral 20mg/kg
1 2 59.6 Oral 20mg/kg
1 4 5.00 Oral 20mg/kg
1 8 6.80 Oral 20mg/kg
1 12 3.46 Oral 20mg/kg
1 24 0.86 Oral 20mg/kg
1 48 0.39 Oral 20mg/kg
1 0 Infusion 100mg/2hrs
1 0.25 12 Infusion 100mg/2hrs
1 0.5 9 Infusion 100mg/2hrs
1 1 8 Infusion 100mg/2hrs
1 2 5 Infusion 100mg/2hrs
1 4 3.9 Infusion 100mg/2hrs
1 8 1.7 Infusion 100mg/2hrs
1 12 1.2 Infusion 100mg/2hrs
1 24 0.9 Infusion 100mg/2hrs
In a single execution how do we execute this data
Should we use filter option ??
Your comments are highly valuable
Regards
K.Harish Kaushik
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If you want to do a single execution, run it as an IV infusion with a rate of 0
for bolus and oral. Keep in mind that in an NCA it is treated as a black box and
nothing matters about where the drug goes so the calculation are the same for
all three methods, but your oral clearance and volume will be apparent (CL/F and
Vz/F) and EV dosing will have to exclude Vss that is calculated. The results
should be the same, but you may want to check by running the oral on its own
just for due diligence.
Ry
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Very easy. In NCA in Setup -> Options under Dose Options drop down menu choose
"Dosing Defined". That will add another column in dosing submenu where you can
select dose type and parameters for each of your runs.
Hope that helps,
Alex
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Hi,
What is the objective of these studies?
If you have this kind of PK data why do you want to use NCA when a compartmental
analysis would be so simple to do and give more information (extent of oral
bioavailability, rate of oral absorption, clearance, intercompartmental
clearance and volumes of distribution; test of hypotheses about
concentration/dose dependence of absorption/distribution/elimination)?
Nick
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The following message was posted to: PharmPK
Harish,
While building worksheet give different Subject ID (u have given "1" to all
routes, instead give 1,2, or 3 for each route), then time, conc, treament, and
dose.
Execute NCA analysis, in "Set up" menu, select "Main worksheet" and do the
"mappings". Put "Subject ID" and "Route" in "Sort" and "time" and
"Concentrations" correspondingly. Select "Dosing" in "set up" and then in "Dose
type" select "Dosing defined" and do as Alex said "That will add another column
in dosing submenu where you can select dose type and parameters for each of your
runs".
Hope this helps.
Regards
Yunus
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Hi Harish,
As Nick rightly suggested, define your objective clearly. Execution of single
run is possible as mentioned by other members but it would be better to use
simple methods to avoid confusion and review the proper data.
Regards,
Kanthikiran Varanasi
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