PharmPK Discussion List Archive - 2015

• 90% CI of ratio of SDs for NTI drugs
• A new book on Model Communication
• Accuracy and precision
• Allometric scaling from animal to human with topical dosing
• Attempt to replicate SAS code for reference-scaled bioequivalence
• Average number of clinical studies
• BCRP DDI Studies - Substrates and Inhibitors
• Blood partitioning
• Calculating time above (or below) a set concentration in Phoenix
• Chronopharmacokinetics study - Analysis
• Clinical Use of PK/PD models
• Cmax of single dose from multiple dose steady state BE study
• DDI PK Guidance
• Different CL by "if" language in Phoenix Modeling Language
• Does BE need to be shown on multiple dose levels
• Does increase in dilution change concentration in urine
• Drug with renal clearance exceeding PAH clearance
• Fatty food increase compound exposure
• Fingolimod Bioequivalence
• Fitting a model to data or data to a model
• How do we account for absorption delays in mPBPK Models
• How do we use models
• If then Else - Phoenix 6.4
• Improving recovery of solid-phase extraction using a Gilson ASPEC XL4
• Intrinsic clearance
• Linear pharmacokinetics of Levamlodipine
• Log/Linear Trapezoidal vs. Lin Up Log Down for NCA of Biologics
• Multiple protein binding
• Olanzapine metabolites
• Oral absorption modeling using Phoenix
• PAPS alternative
• Partial differential equations in NONMEM
• PK gender difference study
• PK Modeling
• PK of Pegylated vs non pegylated IFN molecules
• PK stoppage and Unblinding Issue
• Plotting time on a log scale for illustration
• Potassium salt of anticancer drug
• QT correction for heart rate
• Rat Pooled Liver Microsomes
• Regulatory perspectives on developing traditional medicines
• Releasing BLQ datapoints
• Renewed interspecies website
• Reproducible in vivo PK studies
• Requirement to intersperse the QC samples during study sample analysis
• Retention times of Deuterated internal standard and Analyte
• Running ADAPT 5 in WIndows 8.1 (64 bit)
• SDTM PC and PP datasets from mass balance trials
• Significance of triexponential vs biexponential plasma curve
• Solver tool for excel
• Tetrabenazine Method Development
• Urine volume
• Vss and Vz question
• Whole Blood Stability and Selectivity
• Why extreme high Cmax in animal
• Winnonlin 2-compartment with additive error result

Copyright 1995-2014 David W. A. Bourne (david@boomer.org)