Tracer Kinetics in Biomedical Research

From Data to Model

by Claudio Cobelli, David Foster, and Gianna Toffolo

(C)2000 Kluwer Academic/Plenum Publishers

New York, NY
Library of Congress Catalog Card No. 00-061082
ISBN No. 0-306-46427-6

Table of Contents (456 pages) with CD containing data files for review and SAAM II analysis (Macintosh and Windows format)

1. Introduction

  1. Why Modeling?
  2. How Modeling?
  3. Aim of the Book
  4. Who Should Read the Book
  5. Organization of the Book

2. Fundamentals of Tracer Kinetics

  1. Introduction
  2. The Tracer-Tracee System
  3. The Tracer-Tracee System with Isotopic Tracers
  4. The Radioactive Tracer Variables
  5. The Stable Isotope Variables

3. The Noncompartmental Model of Multipool Systems

  1. From Single to Multipool Systems
  2. Kinetic Parameters of the Accessible Pool
  3. Kinetic Parameters of the System
  4. The Two Accessible Pool Noncompartmental Model: Accessible Pool and System Kinetic Parameters

4. The Compartmental Model

5. Identifiability of the Tracer Model

6. Using the Tracer Model to Estimate Kinetic Parameters

7. Compartmental Versus Noncompartmental Kinetic Parameters

8. Parameter Estimation: Some Fundamentals of Regression Analysis

9. Parameter Estimation in Noncompartmental Models

10. Parameter Estimation in Compartmental Models

11. Precursor-Product Models

Appendices

  1. Relationships amoung Isotopic Variables
  2. The Use of Enrichment in the Kinetic Formulas
  3. Relationship between the Isotopes Ratio and Tracer to Tracee Ratio for Multiple Tracer Experiments
  4. Derivation of Accesible Pool and System Parameter Formulas
  5. Derivation of the Exhaustive Summary
  6. Table of Identifiabililty Results
  7. Obtaining Initial Estimates of Exponentials
  8. Relationship amoung the Parameters of Multiexponential Models
  9. Calculation of Model Output Partial Derivatives
  10. Initial Estimates of the Rate Constant of Multicompartmental Models

Index