Equations for the Estimation of Creatinine Clearance

The Cockroft Equation

It is adequate for most adults patients with normal muscle mass and serum creatinine, Scr < 5 mg/dL:
  • CLcr (male) = IBW (140 - Age) / (72Scr)
  • CLcr (female) = 0.85 IBW (140 - Age) / (72 Scr)
Where: A = age in yrs; IBW = Ideal Body Weight in Kg

The Sanaka equation

For elderly pts (>60) with very low muscle mass and who do not have nephrotic syndrome or severe hepatic disease, the CLcr may be measured directly or estimated by the Sanaka equation (Nephron 1996; 73:137-144 ):

    • CLcr (male) = ABW (19 Alb +32) / 100 Scr

    • CLcr (female) = ABW (13 Alb +29) / 100 Scr

Where: Alb = plasma albumin level (g/dL); Scr = serum creatinine (mg/dL).
ABW = actual body weight in Kg

The metric version of the Sanaka equations
    • CLcr (male) = ABW (2 Alb + 35) / 1.24 Scr
    • CLcr (female) = ABW (Alb + 22) / 0.87 Scr

Where: Alb = plasma albumin level (g/dL);
Scr = serum creatinine (µm/L).
ABW = actual body weight in Kg

Ideal Body Weight (IBW) (kg)
    • IBW (male) = 50 + 2.3 (H - 60)
    • IBW (female) = 45.5 + 2.3 (H - 60)

Where: H = height in inches

The metric version
    • IBW (male) = 0.9 H - 88
    • IBW (female) = 0.9 H - 92

Where: H = height in centimeters.

Dosing Weight
DW = IBW + 0.4 (ABW - IBW)
Where: ABW = actual body wt. in Kg

Jelliffe Equation
Good for adult pts with normal muscle mass and Scr less than 5 mg/dL.
    • CLcr (male) = 98 - 0.8 (A - 20) / Scr
    • CLcr (female) = 88 - 0.7 (A - 20) / Scr

Where: A = age in yrs
CLcr = creatinine clearance in mL/min/1.73 m2

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