CXT-a program for analysis of linear dynamic systems

A description provided by the author

CXT-a program for analysis of linear dynamic systems in the frequency domain, written by Ladislav Dedik and Maria Durisova, published in the International Journal of Bio-Medical Computing 39, (1995) 231-241. In this paper the computer program CXT-(CompleX Tools for Linear Dynamic System Analysis), using the frequency response method, is described and exemplified. The method is based on the approximation of the frequency response of the linear or linearised dynamic system, measured or calculated from input-output measurements, by the frequency model of the system transfer function in the form of the ratio of two frequency-dependent polynomials. The form of the program is sufficiently general to permit application in many areas, e.g. in modeling linear or linearised pharmacokinetic systems consisting of several subsystems arranged in serial and/or parallel fashion, with or without time delays. The program is a menu driven software taking data from a keyboard or disk file to produce outputs on a screen, printer, or disk file in tables and plots. The program can run interactively or in an automatic tutorial mode, under DOS and/or WINDOWS. Numerical examples are taken from pharmacokinetics and indocyanine green liver function tests.

Until now, the program has been used in the following papers:

  1. Dedik L and Durisova M: Frequency response method in pharmacokinetics, J Pharmacokin Biopharm, 22 (1994) 293-307.
  2. Durisova and Dedik L: Comparative study of human pentacaine pharmacokinetics in time and frequency domain, Meth Find Exp Clin Pharmacol, 16 (1994) 219-232.
  3. Durisova, M., Dedik, L., Balan, M.: Building a structured model of a complex pharmacokinetic system with time delay. Bull Math Biol 1995, 57: 787-808.

Upon request, a version of the program will be sent on receipt of a floppy in a self-addressed floppy disk mailer.

Maria Durisova Institute of Experimental Pharmacology, Slovak Academy of Sciences, 842 16 Bratislava, Slovak Republic, Phone/fax: 0042 7 375 928 e-mail:

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