PharmPK Discussion - Feed-back PK-PD models

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On 25 Sep 2001 at 14:51:16, "bvatul" (bvatul.-a-.ufl.edu) sent the message


Hello All

Could somebody suggest me some references which have PK-PD modeling
based on feed-back mechanisms. i.e., say we have two markers A and B
and the levels of A are dependent on the levels of B (based on
physiological mechanism).  The drug has an effect on marker A.

Thanks in advance

Atul

Venkatesh Atul Bhattaram
Post-doctoral fellow
University of Florida

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On 27 Sep 2001 at 10:38:59, "Piotrovskij, Vladimir [JanBe]" (VPIOTROV.-a-.janbe.jnj.com) sent the message


The latest edition of the book by Gabrielsson and Weiner is a good source of
information about the feedback models.

Best regards,
Vladimir

Vladimir Piotrovsky, Ph.D.
Research Fellow
Advanced Modelling and Simulations
Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463)
Janssen Research Foundation
B-2340 Beerse
Belgium
Email: vpiotrov.-a-.janbe.jnj.com

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