PharmPK Discussion List Archive - 2001

PharmPK Discussion List Frequently Discussed Topics

9-hydroxy risperidone
9-OH risperidone
A sample of clonixin and chlormezanone
AAG
About bioavailibility of sustained release diclofenac capsule
About CyA-Salicylate drug interaction
Absolute bioavailability
Accumulation of lysergic acid diethylamide in fat tissues
Active renal secretion differences?
ADME tissue distribution of drugs
ADME/Toxicology in Drug Discovery
Albumin turnover rate - reference
Alcohol CY induction
Amount of EDTAK2 to use for plasma of rat
Analysis of ramipril in human serum
Analytical method for metimazol
ANDPH Cofactor
Applications of Non-parametric methods
Artificial saliva for dissolution testing
Assay simvastatin in human serum
Atenolol bioequivalence
AUC in peripheral compartment
AUC of a two compartment model with Michaelis Menten elimination kinetics
AUC/MIC ratios for Moxifloxacin and Gatifloxacin
Automated Phenytoin Level Adjustments
AZT PK, permeability
Bayesian Two-Stage PK and PKPD analysis
BE criteria for Food effect BE Studies
Biexponential profile in PBPK
Bile duct cannulation in rats
Bioanalytical method for Topiramate
Bioavailability based on single time point
Bioavailability of gabapentin
Bioavailability of quaternary ammonium compounds
Bioenhancers?
Bioequivalence
Bioequivalence Guidance Question
Bioequivalence of preparations containing IronIII hydroxide polymaltose complex
Bioequivalence study using PDAD
Bioequivalency study
Bioequivalency study of Omeprazole delayed release Cap
Biostatistical Software
Biovailability >1
Biowaiver for extended release products
Blood volume formula
Blood volume measurement
BSA?
Buspirone Vmax and Km values
Butenafine
Calculating half-life
Calculation of the elimination rate constant
Catheterism in the rat (portal and systemic)
Chlorpheniramine metabolism
Clearance
Clearance vs rate constant
Clinical Trial Simulator
Commercial Source of 15N3-midazolam
Compartments compartments
Conversion of micro constants to macro constants
Correlation between LogP & Vd
Criteria for lack of food effect on Cmax
CyA-Salicylate drug interaction
Cyclosporin clearance and steady state
CYP 3A4 activity in gut relative to liver
CYP inactivation
CYP2C19 phenotyping
CYP2C19 substrates
Cystatin-C
Cytotoxic agents
Data of bioavailability and dissolution test
Data on interindividula variation in human physiology
Database of pharmacokinetic parameters
Defining 0.693 correction factor for converting Ke to t1/2
Definitions: CL/F and V/F
Determination of the blood to plasma ratio
Differences in various blood pools
Dosing regimen determination
Double dose
Doxorubicin
Doxorubicin-metabolites
Droperidol PK after a single dose
Drug input function
Drug screens with Effexor (fwd) From [psypharm]
Drugs and acute porphyrias
Effect site concentration of a CNS drug
Elimination half-life oc octreotide
Email contact - PK software companies
Endotoxin dose
Enterogastric recirculation
Enterohepatic recirculation
Equation for 3 compartment modelling
Estimation of PK parameters from bolus + infusion administration
Ethics in BA/BE studies with healthy subjects
Ethosuximide
Evaluation of Efficacy of Prodrugs in mice
Experiment in mouse embryos
Extended dosing of Aminoglycoside /endocarditis
Extended interval aminoglycosides and endocarditis
FDA guideline relating Biowaver
Feed-back PK-PD models
Female Himalayan rabbits
First pass effect
Flow rate in the parenchyma brain
FMO(1)
Food and pharmacokinetics
Food effect
Formulating poorly water soluble NCE's
Formulation for IV dose of lipophilics
Furosemide (frusemide)
Generic Issue-Biowaiver
Gentamicin analysis
Gentamicin dosing
Gentamicin PK
Gentamicin Research
Glucose production rates
Glucuronidation
Gut wall metabolism
Half Value Duration (HVD)
Half-lives of purines and taurine
Help with NONMEM
High Clearance
High or Low Vd
Homocysteine solution's stability
HPLC method for Paracetamol, Ibuprophen and Caffeine letter
HPLC method for S-2 (2-aminoethylamino) ethyl phenyl sulphide dihydrochloride
Hydroxy omeprazole
Hydroxy-Propranolol
ICP-MS Labs
Ideal body weight calculation for adults less than 60 inches tall
in vitro ADME of highly insoluble drugs
in vitro permeability
in vivo drug distribution studies
in vivo intrinsic clearance from in vitro metabolism data
Individual Bioequivalence (IBE)
Induction of THC metabolism?
Influences of designer drugs on the metabolism of THC
Information on Std Anit-TB drugs
Inhibitory sigmoid Emax models
Injection and sampling at the same site
Integrator options
Intestinal CYP3A4
Intranasal absorption
Intratracheal administration of solution to rats
Intravascular mixing - PK model
Introduction to PK
Introduction to Risk Analysis
Introductory PK Courses
Ionization and Lipid Solubility
Is there a drug that may postpone dialysis?
IV versus IP
Ketoprofen SR
Ketoprophen
Ki, inhibition constant
Kinetica chronic oral dosing model?
Kinetica Effect Model
Kinetica Problem
Large molecule IV profile
Lean body mass
Linear vs. non-linear PK
Lisinopril
Log P and Vd
Low fe, TBC, Vd
Lung first pass metabolism
MacQuan software
Marker for Liver Perfusion
Mass Balance Studies
Maximum IV Bolus Volume
Measuring absolute bioavailability using different panels
MEGX analysis
Metabolism
Metabolism and bioavailability (absolute)
Metabolism of glyburide and glipizide
Metabolism studies of unstable compounds
Metabolite characterization
Metabolite kinetics
Microdialysis/Bile duct cannulation in rats
Milk samples!!
Model for IV infusion data
Modeling the absorption function in an IVIVC study
ModelMaker from ModelKinetix Users
Nimesulide parentral preparation
Non-specific protein binding
Nonlinear kinetics
NONMEM help
Nonparametric methods-summary of applications
Normal Physiological Values - a Report
Number of points for Ke
OH-Metoprolol and Desmethyl Metoprolol enantiomers
Omeprazole Bioavailability
Omeprazole interactions
Once daily aminoglycoside dosing
Once daily aminoglycosides
Once Daily Dosing of gentamicin
Organisation of Pharmacometric Modeling
P-glycoprotein
P450
P4504A11 inhibitor
Palm PK program requests
Paracetamol (acetaminophen) half-life
Parental use of sucrose and PEG
Partial metabolic clearance
Peak of blank plasma in HPLC
Perfused bovine eye
PET in Drug Development Conference
Pharmacodynamic variability
Pharmacogenetics
Pharmacokinetic of ambroxol
Pharmacokinetic software search
Pharmacokinetic studies Facilities
Pharmacokinetics literature supporting Pharmacy dosing of aminoglycosides and vancomycin
Pharmacokinetics of trans-dermal glucosamine
Pharmacokinetics/pharmacodynamics of oral forskolin in humans.
Phentolamine continuous infusion
Phosphatases in newborn/preterm children/ infants
Physiological parameters
Physiological Pharmacokinetics
Picolinic acid
PK data after topical administration
PK data after topical administration (Iontophoresis)
PK Design
PK experiment in mouse embryos
PK in special population - pregnant women
PK Lung first pass metabolism
PK Modeling of Heparin
PK modelling in subjects receiving E.C.M.O
PK of ambroxol
PK of modified release morphine, hydromorphone and oxycodone
PK of paroxetine, mirtazapine and citalopram
PK parameters and fecal elimination
PK study with tomudex (raltitrexed)
PK variability of subcuteous applications
PK-PD curve fitting
PK-PD Studies in pain
PK/PD relationship or PK/PD relationships ?
PK/PD software
PK/PD vs Indirect link
pKa and solubility of quercetin
Plasma Content in different species
Plasma proteins
Polymorphism query
Polypharmacy
PPB and in vitro metabolism of highly insoluble NCE's
Predictive performance
Presence of phase II metabolites in the urine despite a very high absolute avail
Product formation linear to time
Protein binding and half-life
Protein Binding calculation
Protein binding using plasma versus serum
Question about metacholine PK
Quote of GEP Box
Radioactivity in feces following iv dose
RADIOwith Drug Interactions
Ramiprilat
Rat intestine perfusion rate
Reference in bioequivalence study
References for normal physiological values
References on Clinical Trial Simulation
References on mathematical modeling
Regulatory requirements
Repeated doses
Replicate designs in BE studies
Request for information
Request for PK data set
Request norfluoxetine
Roxithromycin assay
Scaling clearance
Scaling from recombinant CYP to human liver microsomes
Scientific Calculator vs Organizer for PK
Scopolamine and Buscolysin
Selection of dissolution media
SIMKIN software
Small intestine weight
Software for convolution
Software for PK/PD modelling
Solubility, hydrophilicity and pharmacokinetics
Solvents for Parenteral administration
Source for Rifapentine
Stability of COHB samples
Starting dose to give to rats
Stereo isomers of Ibuprofen: PK/PD evaluations.
Strange PK results
Strategy to find Km/Vmax/Ki ?
Supplier for 6a-hydroxypaclitaxel
Supplier for FLUVASTATIN
Suspicious CL/F vs. CLCR and SGOT values
TDM of anticonvulsants
TDM of Parkinson medication
Therapeutic metoclopramide
Time above MIC ?
Toxicity by oral route
Toxicology references
Treatment of ester prodrug dosing PK blood samples
Two Compartment Absorption Model 1st and 0 order Models
Unusual bioavailability results
Updated PK-parameters for buprenorphine
Urinary Excretion
Use of Population PK Approach in Pre-clinical animal studies
Validation of bioanalytical method for Toxicokinetic studies
Vancomycin and Trough levels
Vd
Vitamin K1 epoxide and 7-hydroxywarfarin
Vitreal kinetics
Vitreal protein binding-altering kinetics
What to do with re-assay results
When to do C14 Studies
WinNonlin compatible with DVF ?
WinNonMix Reference
Writing differential equation is Basic editor
Xipamide

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