PharmPK Discussion - P4504A11 inhibitor

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On 26 Apr 2001 at 20:31:20, Sibel Demirbas Ucpinar (SUcpinar.-at-.cedracorp.com) sent the message


Hi

I am looking for a specific inhibitor for CYP4A11.  Any information
regarding to the matter greatly appreciated.

Thanks

Sibel
sucpinar.-at-.cedracorp.com

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On 27 Apr 2001 at 12:34:37, Fabiana Landoni (landoni.-at-.fcv.medvet.unlp.edu.ar) sent the message


The following message was posted to: PharmPK

Dear Sibel,
There is an interesting page from the Georgetown University Medical Center
containing a list of drugs metabolized by individual cytochrome P450
isoforms as well inhibitors and inducers of each enzyme.

http://www.Drug-Interactions.com

Hope it helps
			Fabiana Landoni

Prof. Dra  Maria Fabiana Landoni, PhD
Catedra de Farmacologia.
Facultad de Ciencias Veterinarias
Universidad Nacional de La Plata
FAX +54-221-425-7980
Calle 60 y 118 cc 296
(1900) La Plata.
ARGENTINA

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On 27 Apr 2001 at 12:35:14, Damaris =?iso-8859-1?Q?D=EDaz?= (ddiaz.-at-.medicina.udea.edu.co) sent the message


The following message was posted to: PharmPK

Dear professor Sibil:
For CYP4504A11 there are no much inhibitors describes in the literature.
But this informatios could be useful:
10-(Imidazolyl)-decanoic acid, potent inhibitor (suggested as
selective/test inhibitor)
Ref: Oglivie BW, Otradovec SM, Paris BL, Scheinkoenig JA, Carrott PW,
Loecker SP, Hanzlik RP, Parkinson A, Madan A. 10-(imidazoly)-decanoic
acid (10-IDA) is a selective and potent inhibitor of CYP4A9/11 Drug
Metab Rev. Abstracts from the 10th North American ISSX Meeting,
Indianapolis, IN, USA, Oct. 24-Oct. 28, Vol. 32, Abs. 188, p. 230, 2000.

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