Back to the Top
Dear friends:
We are working in pk/pd diltiazem in acute atrial fibrillation
patients. Could anyone inform me about a validated HPLC technique to
determine diltiazem in human serum?
Juan Pablo Ordov=E1s Baines
Pharmacy Service. PK Lab.
Hospital Dr. Peset
email: farmpese.aaa.san.gva.es
Web: http://193.144.108.96/FarmWebPeset
Back to the Top
You may wish to consult the following reference with reagrd to a validated
method for diltiazem:
Drug Metabolism & Disposition. 24(1):28-33, 1996 Jan.
Richard A. Sams, PhD
Professor and Laboratory Director
Analytical Toxicology Laboratory
College of Veterinary Medicine
The Ohio State University
Telephone: 614-292-5730
=46ax: 614-292-4299
email address: sams.3.-at-.osu.edu
Back to the Top
Dear Juan,
We developed a validated HPLC method to determine diltiazem and its
metabolites in human plasma. The article can be found in Journal of
Chromatography (Biomedical applications), 582 (1992) 203-209. It also
has the reference for other HPLC methods.
M. Delwar Hussain
School of Pharmacy
University of Wyoming
Laramie, WY 82071-3375
Tel: (307) 766 6129
=46ax: (307) 766 2953
e-mail: delwar.-a-.uwyo.edu
Internet:http://plains.uwyo.edu/~delwar/
Back to the Top
Here is a reference for diltiazem assay;
High-performance liquid chromatographic assay for diltiazem in
small-volume blood specimens and application to pharmacokinetic studies
in rats
Scully, P., Meehan, E. and Kelly, J.G.
Journal of Chromatography A
Volume A729, Issue 1-2, 5 April 1996 page 297-300
Chandrani Gunaratna, Ph.D.
Senior Research Chemist
Bioanalytical Systems
2701 Kent Avenue
West Lafayette, IN 47906
Phone: (317)463-4527
E-Mail: prema.-a-.bioanalytical.com
Back to the Top
Greetings!
Virgil Dias at Hoechst Marion (when it was Marion Merrill Dow) published
a PK/PD series about IV diltiazem in 1992. He would seem like a
reasonable place to start. His article was in Circulation 1992;86:1421-8.
I hope this information proves useful.
Best regards,
Dr. Vince Pearson
Drug Information Pharmacist
The Johns Hopkins Hospital
Baltimore, Maryland USA
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)