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Hi David! Could you please send the following message to an appropriate
group, PharmPK discussion group, perhaps? Thanks!
Does anyone who teaches undergraduate pharmacokinetics include
physiologic-pharmacokinetic modeling in their course? If you do, how
detailed is it? If you don't, may I ask why you do not think it is
appropriate for an undergraduate class? Please send your responses directly
to me if you think the group may not be interested in this topic. Thank you
in advance.
Sumati Rao, Ph.D.
College of Pharmacy
Ohio Northern University
419-772-1934
s-rao.aaa.onu.edu
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I teach physiological-based pharmacokinetic modeling to graduate students in
pharmacology and toxicology at the University of California-Davis, however,
I see no reason why this could not be included in an undergraduate course in
pharmacokinetics (upperclassmen) as well. I think the main limitation to
consider in teaching PBPK is related to the math involved since it is hard
to get around expressing the model as differential equations and typical
life science undergrads (and grads) will often have no or only limited
exposure to this. I teach PBPK modeling as one lecture out of a 5 lecture
sequence in pharmacokinetics. Because of the time limitations, I present the
material as an overview of the subject, more importantly, the approach I use
is practical. That is, I show the exact steps involved in developing a PBPK
model. I do try to limit the math content to two differential equations: one
for nonmetabolizing organs and one for the liver, since these will be
representative for most tissues and models. I place the most emphasis on
discussing how PBPK modeling fundamentally differs from classical
pharmacokinetic modeling (compartmental)--indeed this I feel is the most
important point of the lecture and one that could be readily handled by
undergrads. Feel free to email me directly if you would like any additional
tips or information.
Paul Damian
At 12:13 PM 4/25/97 -0500, you wrote:
>PharmPK - Discussions about Pharmacokinetics
> Pharmacodynamics and related topics
>
>Hi David! Could you please send the following message to an appropriate
>group, PharmPK discussion group, perhaps? Thanks!
>
>Does anyone who teaches undergraduate pharmacokinetics include
>physiologic-pharmacokinetic modeling in their course? If you do, how
>detailed is it? If you don't, may I ask why you do not think it is
>appropriate for an undergraduate class? Please send your responses directly
>to me if you think the group may not be interested in this topic. Thank you
>in advance.
>
>Sumati Rao, Ph.D.
>College of Pharmacy
>Ohio Northern University
>419-772-1934
>s-rao.-at-.onu.edu
>
**********************************************************************
Paul Damian PhD, MPH phone (916) 752-7507
Program Coordinator, Western Region fax (916) 752-0903
Food Animal Residue Avoidance Databank farad.aaa.ucdavis.edu (FARAD)
Dept. of Environmental Toxicology pdamian.at.ucdavis.edu (personal)
University of California
Davis, CA 95616
**********************************************************************
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> Does anyone who teaches undergraduate pharmacokinetics include
> physiologic-pharmacokinetic modeling in their course? If you do, how
> detailed is it?
I give one lecture to 2nd year medical students on flow limited
clearance. This covers the basic concepts of intrinsic clearance, organ
clearance and extraction ratio. Examples of high extraction ratio e.g.
morphine and low extraction ratio e.g. theophylline, are discussed in
terms of clinical implications of decreased hepatic blood flow. Note
that theophylline is used to show that decreased flow and thus delivery
of metabolic co-factors, such as oxygen, can decrease organ clearance
even though the intrinsic clearance of theophylline would not predict
this.
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, Private Bag 92019, Auckland, New Zealand
email:n.holford.-a-.auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556
http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.html
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)