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An Open Question:
We are investigating the ability of Bayesian forecasting to accurately
predict the Vancomycin dosage requirements in the premature neonatal
population at the British Columbia Children's Hospital. From reviewing
the literature it seems that the Abbott-Base software has been popular;
however, the program requires height and serum creatinine levels, which
are not routinely measured, in order to proceed with the estimation
routine. Has this problem been encountered by other investigators, and
is there a way to circumvent this program requirement or is there a
better program available? Rebecca Wrishko (wrishko.aaa.unixg.ubc.ca)
University of British Columbia/BCCH
Faculty of Pharmaceutical Sciences
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Rebecca Wrishko wrote:
The Abbott software (PKS) uses height and serum creatinine to estimate
creatinine clearance (CLcr). This is required because this software
expresses CL (and sometimes Vd) as a function of CLcr. However, you can
parametrize the pharmacokinetic model (with the "SETUP" program) in such
a way that it uses only the total clearance of the drug (i.e. no term
relative to CLcr). Then, simply give an arbitrary value for height, and
no value at all for serum creatinine.
Sincerely
--
Jean Debord
Faculte de Medecine
2 Rue du Docteur Marcland
F-87025 Limoges, France
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)