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Hello
I am a doctorate student of pharmacology, I am going to begin a
project related to the influence of changes in protein binding on the
pk/pd relationship. Can someone help me to obtain information about
that item?
Any direction for books chapter, journal, etc will be greatly appreciated
Jose Perez-Urizar
Pharmacology Student
CINVESTAV-IPN, Mexico
ppurizar.at.mpsnet.com.mx
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Dear Jose,
My paper in Journal of Pharmacokinetics and Biopharmaceutics 24:45-77
(1996) could be a starting point for your studies.
Best regards,
Johannes H. Proost
Dept. of Pharmacokinetics and Drug Delivery
University Centre for Pharmacy
Groningen, The Netherlands
tel. 31-50 363 3292
fax 31-50 363 3247
Email: j.h.proost.-a-.farm.rug.nl
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Dear Jose-Perez:
I actually came across a paper which I believe might be quite useful for
your project. It is entitled " An extended PK/PD model describing
quantitatively the influence of plasma protein binding, tissue binding,
and receptor binding on the potency and time course of action of
drugs",by Proost, J.H. et al. J. Pharmacokinetics and Biopharmaceutics,
Vol. 24, No. 1, 1996.
I hope you find it of value to your project.
Suliman I. Al-Fayoumi, Ph.D Student
Dept of Pharmaceutics
Univ. of Florida
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