Back to the Top
Does anyone in this discussion group know of sources that would give data on
human variability of acetylcholine esterase in blood? Is such variation related
to effects on health?
--
Michael C. Kohn
Laboratory of Computational Biology and Risk Analysis
National Institute of Environmental Health Sciences
P.O. Box 12233, Mail Drop A3-06
Research Triangle Park, NC 27709-2233
Telephone:
919-541-4929 (voice)
919-541-1479 (fax)
e-mail:
kohn.-a-.valiant.niehs.nih.gov
Web site:
http://valiant.niehs.nih.gov
Back to the Top
[Two replies - db]
X-Sender: mazoit.-a-.MAILHOST.POP.u-psud.fr
Date: Mon, 09 Aug 1999 11:14:51 +0200
To: PharmPK.-at-.boomer.org
From: "Jean-Xavier.Mazoit.at.kb.u-psud.fr"
Subject: Re: PharmPK ACh esterase in humans
Dear Michael,
At 11:51 06/08/99 -0500, you wrote:
>Does anyone in this discussion group know of sources that would give data o=
n
>human variability of acetylcholine esterase in blood? Is such variation
related
>to effects on health?
I am not sure to have fully understood your question. If you are
interested in the specific acetylcholine esterase bound on cell membrane at
the synapse site, I guess that people interested by Altzeimer disease may
give you authorised advice. If you are interested in
butyril-cholinesterase and other pseudocholineterases found in plasma, see
Pantuck EJ. Plasma cholinesterase: gene and variations. Anesth Analg
1993; 77: 380-6. This is a very good review on an important subject for
anaesthetists because these enzymes are involved in the degradation of
succinylcholine and ester local anaesthetics like procaine and tetracaine.
Try also Goodman and Gilman's book which is always an excellent source of
information.
Regards
Jean Xavier Mazoit MD, PhD
Laboratoire d'Anesth=E9sie
Universit=E9 Paris-Sud
Facult=E9 de M=E9decine du Kremlin-Bic=EAtre
F-94276 Bic=EAtre France
Tel. (33) (0)1 49 59 67 35-37
(33) (0)1 45 21 34 41 (Hopital)
Fax (33) (0)1 45 21 28 75
e-mail Jean-Xavier.Mazoit.-a-.kb.u-psud.fr
---
From: Bernhard.Ladstetter.aaa.merck.de
X-Internal-ID: 37AE823900000D8C
X-Lotus-FromDomain: MERCK
To: PharmPK.aaa.boomer.org
Date: Mon, 9 Aug 1999 11:59:28 +0200
Subject: Antwort: PharmPK ACh esterase in humans
Michael:
The most comprehensive paper I know on this issue is: "Cholinesterases" by
Mary Whittakker, monographs in human genetics, Vol. 11, 1986 (ISBN
3-8055-4257-7).
In chapter 5 you will find genetic variants, in chapter 8 ethnic
distribution and in chapter 9 cholinesterase in clinical medicine.
I hope that helps,
Bernhard
Bernhard J. Ladstetter, PhD
Institute of Pharmacokinetics & Metabolism
Merck KGaA
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)