PharmPK Discussion List Archive - 1999

PharmPK Discussion List Frequently Discussed Topics

18F concentration for a PET study.
A basic question on pharmacokinetics
A message from AAPS
A novel Bayesian dose escalation approach - EWOC
AAG
Abamectin pharmacokinetics
About Carboplatin and Cisplatin
Absorption from multiple tablet doses
Absorption studies
Academic PK Software Plan
ACh esterase in humans
Active Renal Secretion
Acute poisoning
Adult-Children Pharmacokinetics comparison
ADVAN3 TRANS3 Problem - modelling vancomycin and gentamycin pharmacokinetics
Alcohol CY induction
Alloxan use and pk
Analysis of 3-treatment bioequivalence studies
Animal model - skin
Antibiotics and Intraocular penetration
Anticoagulent Choice in Clinical Trials
Approved protocols for Nonclinical and clinical evaluation
Arithmetic vs Harmonic Means for PK parameters
ASCPT conference, pharmacometrics section meeting
Assay for PK of a new Fluoroquinolone antibiotic
Assay of Liposomal Drugs
Atenolol bioequivalence
Atorvastatin
AUC Debate
AUC low after IV Administration
AUC question - Sparfloxacin
Automatic plasma collection
BE question?
Bioavailability and ROA
Bioavailability greater than 1
Blood collection from vein
Blood volume from rat
Blood-brain-barrier drug transfer
Busulphan kinetics
Caco-2 cells
Calculation for multiple dose data
Cassette dosing/cocktail dosing/sample pooling approach
Change in tmax with dose
Chiral separation
Chronopharmacokinetic
Clinical trial failures
Clinical Trials Simulations
Concentration Dependent Protein Binding
Convolution Software
Covariates...
Crystal structure and drug absorption
Cyclosporine Assay
CYP 450 Inhibitors
CYP2E1 and diabetic mice
CYP450 interactions and hepatic extraction ratio
Dapsone hydroxylamine metabolite
Deconvolution as a "stand alone" programme
Design & Analyses of Pharmacodynamic studies: References ?
Differences between methadon and DL-methadon racemate
DiffusiMax - transdermal delivery
Direct transport of molecules from nose to the brain
Discussion archive are now online
Distribution phase
Dose of HONEY for rabbits
Drug absorption and the frequency domain
Drug metabolism
Drugs and Breastmilk
Drugs for Pharmacokinetic study
Educational Information
Effective half-life
Effective half-life and multiple dosing
Eliminated by organ-independent mechanisms
Elimination phase kinetics
Enantiomer suppliers
Ephedrine HCL Data
Equipotent doses of dopaminergic antiparkinson agents?
Esterase inhibitor?
Esterases
Estimate of Heam in the Cytochrome
Ethinyl estradiol
Examples of repeated measures dose ranging studies
Excel add-in needed
Excretion rate vs concentration
Extended release formulations
Flip-flop kinetics
Flukonazole HPLC with fluorometric detection
Formulations for scFv IV use in man
Fractional clearance
Free drug determination
g liver weight/kg body weight
GastroPlus software
Glass tissue homogeniser for prepration of microsomes
GLP in Pharmacokinetics Studies
Guidelines for a PK curve
Gum manufacturers
Half-life problem discussion
Hepatic and renal enzymes
HPLC assay for Arteether
HPLC assay for aspirin
Hu-growth hormone pharmacokinetics in rats
Human Bone source
Hydroxyphenobarbital
I125 ethynyl-estradiol
ICP-MS analysis
Immunoadjuvanta
In need of Cyclosporine D
Inconsistent data during a clinical trial
Increasing AUC metabolite/AUC parent drug % ratio
Inducing liver enzymes in rats
Info on albendazole and its metabolite
Inhibitor of purine nucleoside phosphorylase
Integration of compartmental models
Intestinal drug transport
Intralesional injection of Kenalog and Depo-Medrol
Intro PK/PD and Ba/Be short course
Iron preparations
Is there any book for clinical pharmacokinetics cases
Isomannide mononitrate
Java PK applet
Ka for dexamethasone
Ketamine/norketamine
Ketoconazole questions
Ketoconazole transport
Kinetica Software experience
Kinetics help needed
Kinetics programs
LC/MS/MS vial adsorption problem
Lets get rid of AUC from PK and maybe PD...
List Info
Log P troglitazone
Lovastatine AUCs
Low bioavailability drugs list
Maximum blood draw - rat
Maximum dose of Clavulanic acid
Maximum volume
MDCK cell model
mephenoxalone PK
Metabolism in Liver and Intestine
Metabolism of glyburide and glipizide
Metronidazole pharmacodynamic in c. difficle
Midazolam Binding to Plastic or Glass Containers
Minipigs with induced diabetes
Model for determining release of drug in bone
Modelling local PK-PD
ModelManager - PK Software
Monoamine Oxidase B Half-life
Multiple peaks in oral profile
Nasal and Rectal absorption in the rat
New PK Software - Reviewers needed
Non-compartmental analysis
Noncompartmental analysis assumptions?
Norfloxacin
Nucleic acids extraction
Number of cells/ liver weight
On pk/pd of rhu-GH
Overestimation of AUC
P450 Modulation due to diabetes in mice
PB/PK model
PBPK software for mixtures
PCNONLIN Install Problems
Pharmacodynamic Equation
Pharmacodynamics of quinidine
Pharmacokinetic books online
Pharmacokinetic data
pharmacokinetic of muscimol
Pharmacokinetic software
pharmacokinetics and carrier systems or prodrugs
Piroxicam determination
PK modeling in drug targeting
PK of bolus following infusion???
PK of pro-drugs
PK questions
Pk Ribavirin measurement
Pk-(3H)cholesteryl hexadecyl ether
PK-PD modelling - a very basic question
PK/PB model required
PK/PD
PK/PD modelling
pKa database
PKD journals
PKPD studies
Plasma protein binding of 3-OMD
Pooling samples to get AUC
PopPK and Unblinding of Study Data
Population kinetics
Population pharmacokinetic studies mandatory in EU.
Pramipexole...
Pre/clinical guidelines for evaluation
Predictions of half-life in humans
Propofol protein binding
Protein Binding Study
Protein-binding question
Question from a newbie!
Question regarding PK modeling using a TCI device
Questions Regarding ERMBT
Questions regarding to our study
RACh esterase in humans
Randomized Concentration Controlled Trials
Rapacuronium HPLC
Reconstitution and dialysis of cytotoxic drugs
Reduced peak concentrations
Reference standard of clarithromycin
Reference test substrate (or commonly used) for CYP2C9
Reminders about the list
Resolutions of AST-ALT, LDH and CKMB elevations
Ribavirin measurement
Role of clinical pharmacy in the pharmacy profession
Ropivacaine assay method
SAS PK Macros
SAS PK Package
SC vs PO - efficacy vs availability
Screening and Miniaturization Update
Secretion of drugs in milk in humans and absorption by newborn babies
Simulation of adverse effects
Site with kinetics models
Software for keo
Software to forecast of metabolites of new drugs
Software which will draw S.D on the respective concentration
Sotalol-warfarin interaction??
Statis2
Statistical description of tmax
Statistical review of raw and derived data
Statistical treatment of PK data
Statistics
Sucrose Kinetics
SummitPK - new web address for PK software
Super-hydration with IV erythromycin
Tazobactam assay
TDM of flecainide and propafenone
Techniques to measure drug concentrations in interstitium?
Terminal and biological t 1/2
The responsible use of models
Theophylline sustained release TDM
Time constant approach
Tolmetin metabolism
Topical medicants, especially in pediatric populations
Total BW or BSA for aminoglycoside
Total Falvanoid content assay in Grapefruit juice.
Toxicity tests on mice
Training
Treatment of ester prodrug dosing PK blood samples
Unexpected results - cytokine
Urine volume and feces/24 - mice
Validation of data acquisition systems within a bioanalytical lab
Validation of PK software
Vd for i.v. bolus and constant infusion
Vd smaller than plasma volume
Vehicles for in vivo administration
Volumes of distribution
Warfarin -Plasma Flow Value?
What is "S"?
Where to find a chemical
Which to believe
WinNonlin Deconvolution Question
WinNonlin model - 2C, infusion with MM elimination
WinNonlin model writing?

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